Istradefylline 40 mg/day greater peak stages and AUC of CYP3A4 substrates in clinical trials. This impact wasn't observed with istradefylline 20 mg/working day. Contemplate dose reduction of delicate CYP3A4 substrates.bosentan will minimize the level or result of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.… Read More